Advertisement
Logos Biosystems
Logos Biosystems

Recycling Kidneys

Researchers are trying to use discarded donor kidneys as a scaffold for building new ones.

By | May 23, 2013

FLICKR, BEN ALEXANDERMany kidneys from deceased donors are thrown away each year due to damage. A paper published in Biomaterials earlier this month (May 13) suggests that they could be put to use as raw material for engineering new kidneys.

The study’s authors treated discarded human kidneys with a detergent, which cleared the organ of cells and left only the cells’ extracellular matrices. The eventual plan is to grow the patients’ own cells on the scaffold, producing a kidney that the patients would be less likely to reject than an ordinary transplant. “These kidneys maintain their innate three-dimensional architecture, their basic biochemistry, as well as their vessel network system,” coauthor Giuseppe Orlando, a transplant surgeon and regenerative medicine researcher at Wake Forest Baptist Medical Center, said in a statement.

The scientists tested the scaffold for antigens that might cause a patient to reject the organ and found that they had been eliminated along with the cells. When the researchers transplanted the modified kidneys into pigs and connected their vasculature to the pigs’ circulatory systems, blood pumped through the kidneys at normal pressure.

“With about 100,000 people in the U.S. awaiting kidney transplants, it is devastating when an organ is donated but cannot be used,” Orlando said. “These discarded organs may represent an ideal platform for investigations aimed at manufacturing kidneys for transplant.”

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo
Advertisement

Popular Now

  1. The Mycobiome
    Features The Mycobiome

    The largely overlooked resident fungal community plays a critical role in human health and disease.

  2. Antibody Alternatives
    Features Antibody Alternatives

    Nucleic acid aptamers and protein scaffolds could change the way researchers study biological processes and treat disease.

  3. Simulating Scientific Sabotage, For Fun
  4. Holding Their Ground
    Features Holding Their Ground

    To protect the global food supply, scientists want to understand—and enhance—plants’ natural resistance to pathogens.

Advertisement
PDA
PDA
Advertisement
Life Technologies