Autism Masculinizes Female Brain

Comparative imaging reveals that the brains of women with autism differ from those of women without it in the same ways that the brains of non-autistic men and women differ.

By | August 15, 2013

FLICKR, JASON PRATTThe number of men with autism outweighs the number of women with the neurological disorder, which affects 1 percent of the total population, by a factor of 2:1 to 3:1. As a result, most research has focused on autism’s effects in males, with the assumption that male and female brains are affected in the same way. However, new research published August 8 in the journal Brain demonstrates that autism has different effects on the neuroanatomy of women than it does on men. Further, autism appears to masculinize women’s brains, but not the brains of men.

“One of our new findings is that females with autism show neuroanatomical ‘masculinization,’” senior study author Simon Baron-Cohen, a psychologist at the University of Cambridge, said in a statement. “This may implicate physiological mechanisms that drive sexual dimorphism, such as prenatal sex hormones and sex-linked genetic mechanisms.”

The researchers used magnetic resonance imaging (MRI) to probe for neuroanatomical differences between autistic and non-autistic women as well as between autistic and non-autistic men. They found that the brain areas that differed between women with and without the disorder were the same as those that differ between typically developing males and females, indicating that autistic female brains are masculinized relative to those of non-autistic females. These differences were not seen between brains of males with autism and those without.

“What we have known about autism to date is mainly male-biased,” study leader Meng-Chuan Lai, a neuroscientist at the University of Cambridge, told MedCity News. “We should not blindly assume that everything found for males or from male-predominant mixed samples will apply to females.”

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