Lab-Grown Hair Follicles

Using molecular signatures of human dermal papilla cells grown in a 3-D environment, researchers generate new hair follicles using a patient’s own cells.

By | October 22, 2013

Hair follicle in mammalian skinWIKIMEDIA, CIRCA24Researchers from Columbia University in New York City have developed a technique to grow human dermal papilla cells in 3-D culture that can induce the growth of de novo hair follicles in human skin, paving the way for a new approach to treating baldness. In a paper published in the Proceedings of the National Academy of Sciences this week (October 21), Angela Christiano and her colleagues report a global gene expression analysis of cultured human dermal papilla cells. The researchers found distinct transcriptional signatures between such cells grown in a 2-D versus a 3-D environment. These molecular markers helped them to partially restore the inductive capability of cultured cells, when grown as spheroids.

Using this new approach, the researchers then cultured papilla cells from seven men, which they injected into skin grafts, finding that new hair follicles grew in five. “The dermal papilla cells act as a collective group and restoring that collectivity in 3-D helps bring these properties back,” study coauthor Colin Jahoda from Durham University in the U.K. told New Scientist. “It’s proof of principle for something that has been a roadblock for this particular clinical strategy for many years."

Still, Christiano noted there is more work to be done. “At the moment we’re only getting quite a small hair,” she told The New York Times.

Overall, though, the work is an important first step. Case Western Reserve University skin biologist Radhika Atit, who was not involved in the study, told Science Now that the team’s “work is very elegant and extremely rigorous. . . . This is a big technical advance.”

Add a Comment

Avatar of: You



Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Popular Now

  1. Broad Wins CRISPR Patent Interference Case
    Daily News Broad Wins CRISPR Patent Interference Case

    The USPTO’s Patent Trial and Appeal Board has ruled in favor of the Broad Institute of MIT and Harvard retaining intellectual property rights covered by its patents for CRISPR gene-editing technology.

  2. Henrietta Lacks’s Family Seeks Compensation
  3. Humans Never Stopped Evolving
    Features Humans Never Stopped Evolving

    The emergence of blood abnormalities, an adult ability to digest milk, and changes in our physical appearance point to the continued evolution of the human race.

  4. Abundant Sequence Errors in Public Databases
Business Birmingham