New Alzheimer’s-Associated Genes

A GWAS meta-analysis identifies 11 new loci associated with onset of the neurodegenerative disease.

By | October 28, 2013

Amyloid plaque formations in the brain of a deceased Alzheimer’s patientWIKIMEDIA, JENSFLORIANA meta-analysis of four previously published genome-wide association studies (GWAS) consisting of 17,008 Alzheimer's disease (AD) cases and 37,154 controls has yielded 11 new AD-associated genes. An international team led by investigators at France’s INSERM reported in Nature Genetics this week (October 27) on 11 previously unrecognized susceptibility loci for late-onset AD, which hint at a role for the immune system in the development of the neurodegenerative disease.

According to BBC News, “Alzheimer’s Research UK said the findings could ‘significantly enhance’ understanding of the disease.”

Study coauthor Julie Williams from Cardiff University in the U.K. told the BBC that in analyzing such a large data set, “we've doubled the number of genes discovered and a very strong pattern is emerging. . . . There is something in the immune response which is causing Alzheimer's disease and we need to look at that.”

The National Institute on Aging’s Marilyn Miller lauded the study’s size in an interview with The Washington Post. “Alzheimer’s is obviously a complex disease,” she told the Post, “and because it is so complex, it is only because of this broad-based collaborative effort that we’ve been able to begin to find potential solutions to tackle the disease.”

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo
Advertisement
EMD Millipore
EMD Millipore

Popular Now

  1. Antibody Alternatives
    Features Antibody Alternatives

    Nucleic acid aptamers and protein scaffolds could change the way researchers study biological processes and treat disease.

  2. The Mycobiome
    Features The Mycobiome

    The largely overlooked resident fungal community plays a critical role in human health and disease.

  3. Circadian Clock and Aging
    Daily News Circadian Clock and Aging

    Whether a critical circadian clock gene is deleted before or after birth impacts the observed aging-related effects in mice.

  4. Biologist Resigns Amid Sexual Misconduct Probe
Advertisement
INTEGRA
INTEGRA
Advertisement
Life Technologies