Use of Human Induced Pluripotent Stem Cells for Predicting Diverse Cardiotoxicities

The Scientist brings together a panel of experts to educate you about the successes and caveats of using iPSC-derived cells in toxicological assays.

By | November 18, 2013


FREE Webinar

Wednesday December 11, 2013
11:00 a.m. - 12:00 p.m. Eastern Time
View The Video Now

Accurately predicting cardiotoxicity and elucidating the underlying mechanisms remain vexing and expensive problems for drug discovery. This is due, in part, to the wide range of causes and manifestations. Ion-channel block can lead to acute and delayed arrhythmias, while biochemical toxicities can result in cell death, abnormal cardiac function, and even heart failure and death. Finding physiologically relevant, reproducible, and reliable cell models that can be used to detect these end points at preclinical and discovery stages has been a challenge, as most toxicity testing is done either by using immortalized cancer cell lines, primary explanted somatic cells, or live animals. The development of human induced pluripotent stem cell (iPSC)-derived cell lines as models for drug-toxicity testing offers a promising alternative that is more physiologically relevant, more predictive, and more time and cost efficient. Although iPSC-derived cardiomyocytes have not yet replaced well-established FDA-approved toxicological methods, the FDA has fast-tracked efforts to standardize the use of stem cell-derived cardiomyocytes in the next two years. The Scientist brings together a panel of experts to discuss the successes and caveats of using iPSC-derived cells in toxicological assays. You can interact with the panelists during the live webinar by asking questions and sharing your experiences on using stem cells for toxicity testing, while learning from their expertise.

As an attendee you will gain:

  • A clear understanding of human induced pluripotent stem cell-derived cardiomyocytes
  • The cardiotoxic effects of kinase inhibitors
  • Cellular mechanisms of pro-arrhythmia
  • The use of iPSC-derived cardiomyocytes in the accurate prediction and detection of cardiotoxicity and how they compare to other currently used models

View The Video Now

Meet the Speakers:

Kate Harris, PhD, is a senior scientist in the Investigative Preclinical Toxicology group at GlaxoSmithKline. Harris earned her doctorate from the University of Sheffield, investigating calcium handling in normal and cystic fibrosis airway epithelia. She previously worked as a postdoctoral scientist for two years in GlaxoSmithKline’s Safety Pharmacology group, where her research focused on developing and validating an electrophysiology assay using human induced pluripotent stem cell-derived cardiomyocytes for cardiac safety screening.

Sarah Lamore, PhD, is a postdoctoral scientist at AstraZeneca Pharmaceuticals. Her current research focuses on utilizing cellular impedance measures of human iPSC-derived cardiomyocytes to deconvolute kinase inhibitor cardiotoxicity. She received her PhD in pharmacology and toxicology from the University of Arizona in 2012 for which she identified cysteine cathepsins as novel targets of UVA-induced photooxidative stress.




Add a Comment

Avatar of: You



Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Popular Now

  1. Birth of the Skin Microbiome
    Daily News Birth of the Skin Microbiome

    The immune system tolerates the colonization of commensal bacteria on the skin with the aid of regulatory T cells during the first few weeks of life, a mouse study shows.

  2. Inside a Lab Mouse’s High-Fat Diet
  3. Battling the Bulge
    Bio Business Battling the Bulge

    Weight-loss drugs that target newly characterized obesity-related receptors and pathways could finally offer truly effective fat control.

  4. How Gastric Bypass Can Kill Sugar Cravings
Life Technologies