Using Ingenuity Variant Analysis in Pharmacogenomics

This presentation covers sickle cell disease (SCD), specifically the genetic component to fetal hemoglobin response to hydroxyurea. Such knowledge will enhance the ability to predict drug response, improving patient care by allowing selection of individuals who will benefit most from hydroxyurea, and offer alternative therapies.

By | November 15, 2013

This presentation covers sickle cell disease (SCD), specifically the genetic component to fetal hemoglobin response to hydroxyurea. 

Join us for our latest webinar presented by Vivien Sheehan, Assistant Professor of Pediatrics at Baylor College of Medicine. Sheehan will be speaking about her work in pharmacogenomics. This presentation will cover sickle cell disease (SCD), specifically the genetic component to fetal hemoglobin response to hydroxyurea. Such knowledge will enhance the ability to predict drug response, improving patient care by allowing selection of individuals who will benefit most from hydroxyurea, and offer alternative therapies.

Genes implicated in drug response may also provide insight into the mechanisms by which hydroxyurea induces fetal hemoglobin, and possibly reveal new drug targets. Sheehan will cover her analysis of variants associated with HbF response to hydroxyurea using QIAGEN's Ingenuity Variant Analysis, as well as that of variants associated with endogenous HbF levels.

As an attendee you will learn:

  • How Ingenuity Variant Analysis can be used to analyze variants associated with high or low drug response or drug dosage.
  • That the exonically variable criteria found in the confidence filter can be helpful in eliminating genes with a high degree of variability that may result in false associations.
  • How burden analysis is a valuable addition to the analysis.
  • That the common-variants filter should be used with caution in phenotypes not subject to evolutionary pressure, such as drug response.

Meet the Speaker:

Dr. Vivien A. Sheehan
Assistant Professor of Pediatrics
Baylor College of Medicine

 

Ingenuity

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Popular Now

  1. Gut Microbes Linked to Neurodegenerative Disease
  2. Top 10 Innovations 2016
    Features Top 10 Innovations 2016

    This year’s list of winners celebrates both large leaps and small (but important) steps in life science technology.

  3. Opinion: WHO’s Silence on Cannabis
  4. Image of the Day: Parting Ways
    Image of the Day Image of the Day: Parting Ways

    The Allen Institute for Cell Science releases the first public collection of human induced pluripotent stem cells that have been fluorescently tagged using CRISPR.

Rockland