Advertisement
LabX
LabX

Lab-Grown Kidney Buds

Using human stem cells, investigators from the U.S. and Spain generate functional ureteric buds.

By | November 19, 2013

SALK INSTITUTE FOR BIOLOGICAL STUDIESMini kidneys this week (November 17) joined a growing group of functional organ progenitors, or buds, when scientists from the U.S. and Spain described the differentiation of human stem cells into renal progenitor-like cells in Nature Cell Biology. Other groups had previously created liver buds and cerebral organoids using human stem cells.

Using a 3-D culture system in which differentiated human cells assembled with murine cells, Yun Xia from the Salk Institute for Biological Studies in La Jolla, California, and colleagues generated uretic bud-like structures.

“Attempts to differentiate human stem cells into renal cells have had limited success,” study coauthor Juan Carlos Izpisua Belmonte said in a statement. “We have developed a simple and efficient method that allows for the differentiation of human stem cells into well-organized 3D structures of the ureteric bud, which later develops into the collecting duct system.”

In their paper, the authors suggested that their kidney buds not only provide a new model for studying kidney disease, but also “open new avenues for the future application of regenerative strategies in the clinic.”

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo
Advertisement

Popular Now

  1. LabQuiz: What's Your Cell IQ?
    Sponsored Quiz LabQuiz: What's Your Cell IQ?

    Your body is made up of trillions of cells—but what do you really know about them? Take our lab quiz and determine your CIQ (cell identification quotient). 

  2. Genetic Connections Among Human Traits
  3. Antibiotics From Scratch
  4. Further Evidence that Life Might Have Started with RNA
Advertisement
Advertisement
LabX
LabX
Biosearch Technologies
illumina Corporate
illumina Corporate