Graphene Coating Cleans Up Clots

Blood clots on medical devices might be reduced by a graphene-based material.

By | February 12, 2014

Schematic illustration of graphene-hemin-GOx conjugates.TENG XUE AND NATHAN WEISSProblematic blood clots can form on medical devices, such as artificial heart valves. And anti-thrombotic agents added to medical devices are eventually used up. Scientists reported in Nature Communications this week (February 11) on a potential solution: a coating that catalyzes the production of anti-clotting molecules in blood without the need to add reagents.

The platform supporting the catalysts is made of graphene, a single layer mesh of carbon atoms. Attached to the mesh are hemin molecules and glucose oxidase enzymes, which use L-arginine and glucose present in the blood to produce nitroxyl, an anti-clotting molecule. “The embedment of such tandem catalysts into biocompatible films can create a surface coating with excellent antiplatelet characteristics,” the authors wrote in their study.

Importantly, the generation of nitroxyls is sustained without needing to replenish the coating. According to a press release, the authors show that “blood clotting on a plastic film coated with their material is substantially reduced and remains so even after three days.”

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Avatar of: JonRichfield


Posts: 88

February 13, 2014

Not understood: three days???

Could someone please elaborate on why this is promising? How long is needed for such devices? What happens after the three days? A new heart valve?

Or if clotting no longer matters after three days, why not?

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