Graphene Coating Cleans Up Clots

Blood clots on medical devices might be reduced by a graphene-based material.  

By | February 12, 2014

Schematic illustration of graphene-hemin-GOx conjugates.TENG XUE AND NATHAN WEISSProblematic blood clots can form on medical devices, such as artificial heart valves. And anti-thrombotic agents added to medical devices are eventually used up. Scientists reported in Nature Communications this week (February 11) on a potential solution: a coating that catalyzes the production of anti-clotting molecules in blood without the need to add reagents.

The platform supporting the catalysts is made of graphene, a single layer mesh of carbon atoms. Attached to the mesh are hemin molecules and glucose oxidase enzymes, which use L-arginine and glucose present in the blood to produce nitroxyl, an anti-clotting molecule. “The embedment of such tandem catalysts into biocompatible films can create a surface coating with excellent antiplatelet characteristics,” the authors wrote in their study.

Importantly, the generation of nitroxyls is sustained without needing to replenish the coating. According to a press release, the authors show that “blood clotting on a plastic film coated with their material is substantially reduced and remains so even after three days.”

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Comments

Avatar of: JonRichfield

JonRichfield

Posts: 111

February 13, 2014

Not understood: three days???

Could someone please elaborate on why this is promising? How long is needed for such devices? What happens after the three days? A new heart valve?

Or if clotting no longer matters after three days, why not?

Popular Now

  1. UC Berkeley Receives CRISPR Patent in Europe
    Daily News UC Berkeley Receives CRISPR Patent in Europe

    The European Patent Office will grant patent rights over the use of CRISPR in all cell types to a University of California team, contrasting with a recent decision in the U.S.

  2. What Budget Cuts Might Mean for US Science
    News Analysis What Budget Cuts Might Mean for US Science

    A look at the historical effects of downsized research funding suggests that the Trump administration’s proposed budget could hit early-career scientists the hardest.  

  3. Opinion: On “The Impact Factor Fallacy”
  4. Unstructured Proteins Help Tardigrades Survive Desiccation
Business Birmingham