Rats Receive Lab-Grown Esophagi

Researchers successfully transplant engineered esophagi into living rats.

By | April 16, 2014

After two weeks regeneration in vivo, the esophagus scaffold is covered by a multi-layered, keratinized epithelium.KAROLINSKA INSTITUTEAdd esophagus to the list of organs researchers have engineered in the lab and successfully transplanted into living mammals. A team led by investigators at the Karolinska Institute in Sweden has created esophagi by seeding organ scaffolds with rat bone marrow mesenchymal stromal cells, and implanted the engineered organs in rats without needing to suppress the host immune system. The results were published in Nature Communications this week (April 15).

“We believe that these very promising findings represent major advances towards the clinical translation of tissue engineered esophagi,” study coauthor Paolo Macchiarini, who directs the Advanced Center for Translational Regenerative Medicine at the institute, said in a statement.

The team’s engineered esophagi included not only differentiated muscle cells, but also nerves and blood vessels, which are key to the survival of the implanted organs. (Stay tuned for a May feature on engineering vasculature along with synthetic organs.) “We were really surprised at the level of differentiation we got,” Macchiarini told Live Science.

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Avatar of: Mehrishi

Mehrishi

Posts: 5

April 16, 2014

It is an excellent effort from Edinbergh- an addtional another source of

blood to supplement donated blood supplies. It is not know yet what battery of tests have been done for the quality control, structure, properties, function, survival, life span  and elimination.

We await the assessment by critically important surface markers to be tested  independentyl by a battery of tests.

In November 2011: Published in the peer review journal BLOOD of the Amer Soc Hematol: The proof of principle study of cultivated red blood cells successfully tested in humans :by the French  team of Professeur Luc Douay at Hôpital St Antoine, Paris- after several papers had been published- describing

1. Giarratana MC .... Douay L. Proof of principle for transfusion
of in vitro–generated red blood cells. Blood 2011;
118:5071-9.

 

2. Klein HG. Brewing blood. Blood 2011;118:5069-70.

 

J N Mehrishi, PhD, FRCPath.

Dr J Mehrishi, PhD (Cantab),FRCPath.
 Initiator/coordinator
International, Interinstitutional Cord Blood Stem Cells for Treating Adults Feasibility and Promising Development
The Cambridge Blood, Umbilical Cord Blood Stem Cells for Cell Therapy (Adults /children), cRBC Research Initiative
CD34+ Cell Therapy (Heart Disease), CD34+ Cells Lentiviral Vector Engineered for Hb Gene Transfer Therapy - Thalassemia, Sickle Cell Disease
Macfarlane Cl. 13, Impington, Cambridge CB24 9LZ, United Kingdom. jm45@cam.ac.uk. Tel 44-1223-57 36 28
 

 

Avatar of: Mehrishi

Mehrishi

Posts: 5

April 16, 2014

It is an excellent effort from Edinbergh- an addtional another source of

blood to supplement donated blood supplies. It is not know yet what battery of tests have been done for the quality control, structure, properties, function, survival, life span  and elimination.

We await the assessment by critically important surface markers to be tested  independentyl by a battery of tests.

In November 2011: Published in the peer review journal BLOOD of the Amer Soc Hematol: The proof of principle study of cultivated red blood cells successfully tested in humans :by the French  team of Professeur Luc Douay at Hôpital St Antoine, Paris- after several papers had been published- describing

1. Giarratana MC .... Douay L. Proof of principle for transfusion
of in vitro–generated red blood cells. Blood 2011;
118:5071-9.

 

2. Klein HG. Brewing blood. Blood 2011;118:5069-70.

 

J N Mehrishi, PhD, FRCPath.

Dr J Mehrishi, PhD (Cantab),FRCPath.
 Initiator/coordinator
International, Interinstitutional Cord Blood Stem Cells for Treating Adults Feasibility and Promising Development
The Cambridge Blood, Umbilical Cord Blood Stem Cells for Cell Therapy (Adults /children), cRBC Research Initiative
CD34+ Cell Therapy (Heart Disease), CD34+ Cells Lentiviral Vector Engineered for Hb Gene Transfer Therapy - Thalassemia, Sickle Cell Disease
Macfarlane Cl. 13, Impington, Cambridge CB24 9LZ, United Kingdom. jm45@cam.ac.uk. Tel 44-1223-57 36 28
 

 

Avatar of: Paul Stein

Paul Stein

Posts: 225

April 17, 2014

Add another extremely tiny organ to the list researchers have engineered in the lab and successfully transplanted into living micromammals.  Add another to the list of yawns.  As I have now stated for years, when this is done in a pig, then I'll be impressed.  Until then, how many cures for esophageal cancer in rats are necessary until the rats are finally happy?

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