The Rainbow Connection

Color vision as we know it resulted from one fortuitous genetic event after another.

By | October 1, 2014

SEEING COLOR: Stylized image of the eye’s photoreceptors, the rods and cones, which respond to particular of wavelengths of light to give animals their sense of sight© ALFRED PASIEKA/SCIENCE PHOTO LIBRARY/GETTY IMAGES

In a steamy Eocene jungle, a newborn monkey opens its eyes for the first time. The world it sees is unlike any other known to its primate kin. A smear of red blood shines against a green nest of leaves. Unbeknownst to its mother, this baby is special, and its eyes will shape the human experience tens of millions of years in the future. Were it not for this little monkey and the series of genetic events that created it, we might not have the color vision we do: Monet’s palette would be flattened; the ripeness of a raspberry would be hidden among the leaves; traffic lights? They likely would never have been invented.

Like most other mammals, monkeys that lived 30 million to 60 million years ago had just two opsin genes encoding the photopigment proteins that tune cone photoreceptor cells in the retina to absorb light in a range of wavelengths. Then, an allele of one of the opsin genes mutated, producing a pigment protein that responded to previously unseen wavelengths of light. Later, a region of the allele duplicated and inserted, creating a third opsin gene and solidifying the transition from a landscape of blues and either reds or greens (it’s not certain which opsin came first) into the rich color spectrum that humans and many other primates see today.

Adding a third opsin gene doesn’t simply introduce 50 percent more colors; its effect is multiplicative. If a single opsin gives an animal the ability to distinguish 100 shades, say, the addition of a second opsin, “amazingly, multiplies that by 100,” says color vision researcher Jay Neitz of the University of Washington in Seattle. “Adding a third photopigment has been the greatest invention of all, because it multiplies color vision by another 100 times.”

Such a profound expansion of our visual experience actually required very minor genetic alteration. In 1991, Neitz, working with his wife Maureen and their postdoc advisor Jerry Jacobs of the University of California, Santa Barbara, demonstrated that just three amino acid substitutions account for the 30 nm difference in peak absorption between the modern-day red and green cones in humans, with each change shifting the photopigment’s color spectrum by 5 nm to 15 nm.1 “It’s absolutely stunning,” says Jacobs. “A single nucleotide change can change your color vision.” (See illustration below.) Yet, despite this simplicity, the evolutionary circumstances that allowed our primate ancestors to adopt trichromacy—the three-cone system that gives humans and some other primates the ability to see the world in full-spectrum color—are remarkably intricate.

To understand how that first trichromatic monkey and its similarly equipped primate descendants responded to their heightened sense of sight remains an ongoing quest. But experiments by the Neitzes and others that provide dichromatic animals, such as mice or squirrel monkeys, with an extra opsin are helping to fill in the story of the evolution of human color vision. The results suggest that the first trichromatic monkey may have been able to respond immediately to its new, more vibrant world—see the ripe fruit among the green buds; the red ants on the leaves. The work may also point the way to a future in which scientists could treat color blindness by replacing malfunctioning opsin genes, and perhaps, one day, even supercharge humans’ color perception to reveal a new rainbow altogether.

A colorful duplication

It’s 1980. Jeremy Nathans, then a graduate student at Stanford University, is driving back to campus after visiting a slaughterhouse in San Jose. Beside him jiggles a bucket of cow eyeballs on ice.

He’s heading to the lab of his advisor, David Hogness, where he plans to use the eyeballs, along with a revolutionary new tool called recombinant DNA, to answer a question that had been posed decades before: What is the molecular basis of color vision? “It seemed clear to me that the way to solve these problems was not to study light-absorbing proteins, which are extremely rare, hard to work with, and intermixed with far more abundant proteins,” says Nathans. “This was a problem that was going to be solved by going directly to the genes.”

At the time, very few human genes had been cloned, and recombinant DNA methods were crude. “It was hard,” recalls Nathans, now a professor at Johns Hopkins University School of Medicine. “We went up quite a few wrong paths.” But four years of labor eventually paid off. In 1983, Nathans and Hogness published the amino acid sequence of bovine rhodopsin, and a year later they published the human rhodopsin sequence.2

Rhodopsin, expressed in rod photoreceptor cells, enables animals to see in dim light. To understand color vision, Nathans and his colleagues had to track down the three opsins embedded in the cell membranes of the three varieties of cones, which absorb short (blue), medium (green), or long (red) wavelengths of light. Fortunately, despite about a billion years of divergence between them, rhodopsin and the cone opsin genes shared enough sequence homology for the known sequence to serve as a probe for the unknown genes.

What makes the tale of primate color vision so special is that it can be told, from beginning to end, in exquisite genetic and molecular detail.

A couple of years later, using his own DNA, Nathans and colleagues cloned the cone opsins. Two of them—the red and the green—reside on the X chromosome and are 96 percent similar in their amino acid sequence. The results provided support for the idea that an ancient X-linked opsin gene underwent a single duplication event and that subsequent mutations in the copy shifted the absorbance spectrum of the photopigment.3

“The work illuminates not only the physiology of color vision, but basic mechanisms of evolution,” geneticist David Botstein, now at Princeton, wrote in a commentary accompanying Nathans’s paper in Science. “It has been thought for some time that a major theme of evolution is duplication followed by divergence.”

But, as it would turn out, duplication and divergence are not the whole story.

Around the same time that Nathans was cloning human opsin genes, the Neitzes were working on squirrel monkeys in Jacobs’s Santa Barbara lab. Previously, Jacobs had found that these New World monkeys do not have the same color vision as Old World primates and humans. In particular, squirrel monkey color vision is highly polymorphic—some females see much larger ranges of shades than males or other females.

Digging into the genetics of this unusual variation, Jay Neitz and his colleagues discovered that while squirrel monkeys have just two opsin genes (one on chromosome 7 and one on the X chromosome), they have several opsin alleles. Three alleles, which resemble the human red and green opsins, are present in the same locus on the X chromosome. With just one X chromosome, all males are dichromats, but because females carry two Xs, they can carry two different alleles for the X-linked opsin gene, granting such heterozygotes trichromatic vision.4

“The first step then to getting to trichromacy [in primates] was to just get diversity, polymorphism, in the one gene [they] have,” says Neitz. Then, somewhere along the line a genetic translocation likely plucked an opsin allele from one X chromosome and plunked it next to a different opsin allele on the other X chromosome, giving that animal two opsin genes adjacent to one another, as humans have today.

“The fact that we have the same few amino-acid substitutions as New World monkeys argues there was a single ancestral variation that gave rise to [the cone opsins of] both Old and New World primates,” Nathans says. “It leads to an interesting twist on the evolutionary dogma of gene duplication.”

X marks the spot

In Living Color

Human color vision is based on the different wavelengths of light absorbed by three cone opsin proteins, which are responsible for the spectral tuning of the cone cells in the retina. The red and green opsins, whose genes reside on the X chromosome, are thought to have evolved from an ancestral cone opsin gene that duplicated itself.

THE SCIENTIST STAFF

Three amino acid substitutions in the red opsin protein account for the spectral tuning of the green opsin. At position 180, swapping serine for alanine produces a 6 nm shift of the absorption spectrum; tyrosine to phenylalanine at position 277 provides a 9 nm shift; and changing a threonine to an alanine at position 285 confers another 15 nm shift in maximum absorption. Together these three changes produce the 30 nm gap between the maximum absorption of the red and green opsins.

OPSIN PROTEIN ADAPTED FROM FIGURE COURTESY OF JAY NEITZ AND SCIENCE, 252:971–74, 1991.

While a gene duplication of the X-linked opsin was necessary to grant all the animals in a group, including the males, trichromatic vision, this part of the color vision story is, once again, not so simple. There needed to be some mechanism to ensure that both genes on the X chromosome were not coexpressed in the same cone cell.

The prevailing model for how the brain discriminates colors is that it assigns cone classes—green, red, or blue—to each cell by comparing how it and its neighbors respond to various wavelengths. For instance, if red light hits the eye and one cone activates while an adjacent cone stays silent, then the brain figures out that those two are in different cone classes. But cone cells are only useful in discriminating colors in this way if each cell expresses only one type of opsin. If an individual cone carried two different opsins and responded to the absorption spectra of each, its firing wouldn’t be very informative. So how do cone cells, which carry an organism’s full genome and thus the genes for all three opsins, limit the expression of two of them?

Researchers are still unsure how the blue opsin gene, positioned on an autosomal chromosome, is not coexpressed with either of the opsins on the X chromosome, but Nathans’s work has yielded clues regarding the mechanism that allows only one of the two X-linked opsins to be expressed in a given cell. Studying people who have only one functional opsin that absorbs short wavelengths of light and can thus discriminate only among blue hues, Nathans discovered that some of these so-called blue-cone monochromats had deletions about 4,000 base pairs upstream of the red and green opsins on the X chromosome.5 “It smelled like an enhancer,” says Nathans, referring to short genetic sequences adjacent to promoters that help initiate transcription. He later showed in transgenic mice that this enhancer sequence is required for the expression of red and green opsins and that it selects which one will be transcribed.6

Importantly, the opsin gene duplication on the X chromosome did not include the enhancer, resulting in a single enhancer being responsible for turning on both genes. But it acts on only one opsin gene in any given cell—likely chosen at random—meaning that the enhancer will lead to the expression of the red opsin in one cone and the green opsin in another. Without this mechanism, cones would likely express a gobbledygook of green and red opsins, and our perception of color would be drastically different.

Brain power

Whether that first trichromatic monkey could actually take advantage of the expression of all three opsin alleles—whether it could see the blood on the leaves as a different color—is not entirely clear. And in fact, a basic quandary in evolutionary biology is how animals process new sensory input. “When she got this new cone, did she say, ‘Great, this is a nicely colored world,’” says Jacobs, “or did she say, ‘Oh, now I suppose I have to redesign my nervous system’?” Around 2000, he and Nathans got the opportunity to answer that question.

The researchers replaced one of the medium-wavelength opsin alleles on the mouse X chromosome with a human long-wavelength opsin gene to create a line of trichromatic mice. They then trained the mice to select the color in a panel of three that differed from the other two. Next, the mice were tested for their ability to perform this task across a range of shades, including those within the absorption spectrum of the new opsin. The newly trichromatic animals excelled at the task. In 2007, the team published data showing that heterozygous female mice, which carried the long-wavelength gene on one X chromosome and the medium-wavelength gene on the other, plus their short-wavelength gene on chromosome 6, were able to discriminate additional colors compared to animals with only medium- and short-wavelength alleles. This suggested that the animals’ brains were making use of the new opsin.7 “I think that’s the cool part of it, that [plasticity] is just an intrinsic property of a sophisticated nervous system like a mammal’s,” says Nathans.

A couple of years later, the Neitzes and their colleagues tried something similar with adult squirrel monkeys, using viral-vector gene therapy to introduce a third cone opsin into full-grown males. In this case, the animals were not immediately able to discriminate colors, but after about four months, the monkeys showed marked improvement, detecting previously indistinguishable colors in blue-green and red-violet hues.8 The delay corresponded to the timing of robust transgene expression, as if having the new visual pigment was all it took. “Marvelously, the monkeys gained what looks like full trichromatic vision,” says Jay Neitz, adding that the effects remained stable for a few years.

Both studies suggest the possibility that the primate brain was primed to accept the new stimulus offered by a third cone opsin—no major rewiring required. Such an ability may reflect our far-distant ancestors’ perception of even more colors than we see today. “If you go back to the vertebrate ancestor, they used to have five different kinds of pigments,” says Shozo Yokoyama, who studies vertebrate opsins at Emory University. Mammalian ancestors presumably lost some of these opsin genes along the evolutionary way, but their brains may have retained the capability to interpret the activity of additional opsins. (See “Animals’ Diverse Palettes” at bottom.)

But others in the field aren’t convinced that the animals were able to process new colors as soon as the retinal hardware was in place. Shortly after Nathans’s mouse study came out, Walter Makous, a vision science researcher at the University of Rochester, commented in Science that the mice might not be discriminating colors with their new opsin. Rather, they could have detected blotchiness in the color presented as a result of the human and mouse cones responding differently to the same stimulus, as if they were detecting different luminosities of the same color.9 It’s possible then that true color vision does not explain the mice’s improved performance. Instead, the brain “could see changes in color as essentially changes in texture,” says David Brainard, a vision scientist at the University of Pennsylvania. “Or it could be the brain is primed to figure this out and gives you color vision. I don’t think we know.”

A recent modeling study by Brainard’s group points to the latter scenario, at least for primates. The research team used computer learning to simulate human color vision and found that the configuration of the human retina—its particular mosaic of cone types, the ratio of long- to medium-wavelength cones, and the differences in their maximum absorption spectra—allows for such learning.10 These variables present the brain with enough information to determine the class (red, green, or blue) of each cone based on the wavelengths that each cell responds to.

“It was possible for the information-processing system to observe the signal of a cone and successfully assign labels for each cone class that are highly accurate,” Brainard says. Whether that was the case when trichromacy first appeared among primates is not certain, but Brainard’s simulation demonstrates that the modern human retina can make use of three opsins. Given the similarities among primate retinas, perhaps the first trichromatic monkey could do the same.

Colors with benefits

At whatever point primates were able to perceive additional color, the advantages would have spurred trichromacy’s quick spread through the population, researchers presume. It’s been thought that the monkeys would have been able to better distinguish between ripe and unripe fruit, for example, and to spot reddish young leaves among less protein-rich older ones, allowing them to forage more efficiently and improve the nutritional quality of their meals. (See photographs here.) But demonstrating the existence of such benefits has proven difficult.

PLOS ONE, doi:10.1371/journal.pone.0084872.g001, 2014. PHOTO CREDITS PRIMATES: F. CAMPUS; FRUITS: A. MELIN; PUMA: N. PARR

Amanda Melin of Washington University in St. Louis has spent years traveling to the forests of Costa Rica to observe capuchin monkeys in their natural habitat. Like squirrel monkeys, these New World primates have dichromatic males and either dichromatic or trichromatic females. Melin spends days at a time watching the animals forage, walking kilometers through the forest as the monkeys move from tree to tree, and collecting DNA from fecal samples, in an effort to determine which colors each animal can see. Much to her surprise, she’s found that fruit feeding rates between dichromats and trichromats are the same, initially suggesting that color vision doesn’t offer an advantage for foraging.11

Digging deeper into the data, however, Melin uncovered a subtler effect. “Where we see the difference is in accuracy,” she says. “Trichromats are making way fewer mistakes, but foraging at a more leisurely pace.” Dichromats, on the other hand, appear more frantic, touching, sniffing, and biting more fruits, including unripe or inedible ones.12 The question Melin is trying to answer now is whether that sloppier foraging behavior has any nutritional impact on the animals.

For people, of course, the importance of color vision is immeasurable, and Neitz is hopeful that the gene therapy he has used in monkeys could translate to a therapy for patients with color blindness. If successful, this would not only bring color acuity into the lives of those whose color experience is limited, it would allow researchers to explore how humans experience the leap from dichromacy to trichromacy.

But why stop there? Neitz wonders if it might also be possible to expand the range of normal human vision. This summer, he used gene therapy to give two monkeys a fourth cone opsin, such as birds have. Its absorption peak sits between that of the short- and medium-wavelength opsins, somewhere between violet and green. As this article goes to press, it’s too soon to know whether the supplemental gene has given the monkeys added sensitivity at that end of the rainbow, but if it works, the monkeys may soon be able to see 100 times more colors. It is enticing to think of how such a therapy could enrich human vision. Would a forest no longer look homogeneously green, but as diverse in hue as it is in individual trees? What beauty might we experience in art if we are able to perceive an order of magnitude more colors?

“Sometimes when I’m driving around I ask myself if the IRB [institutional review board] would let me do that to myself,” says Neitz. Why not try it out, he muses, to see if he can “cure” himself of trichromacy? Indeed, whether it happens by the hand of evolution or by human intervention, perhaps the story of human color vision’s progression is not over, Neitz says. “It’s a brave new world.” 

         

 ANIMALS' DIVERSE PALETTES | See full infographic: JPG | PDF
 

Most mammals, such as dogs, express just two types of opsins in the distal ends of their eyes’ cone cells, which are responsible for color vision. Humans and some primates have three. Other animals, including birds, fish, and insects, have even more opsins, although insects don’t have cones, but instead use other types of cells to detect color. Such diversity yields whole new worlds of color, with each opsin adding an order of magnitude more hues. Reconstructing the evolution of opsin genes, Shozo Yokoyama of Emory University and his colleagues have found that substitutions at only a couple dozen amino acid sites in opsin proteins account for this diversity of spectral tuning found among vertebrates.

© MALEXEUMLike most mammals, dogs (Canis familiaris) see in color, just far fewer colors than other animals. From a behavioral study of two Italian greyhounds and a toy poodle, researchers figured out their limited color discrimination is due to dichromatic color vision (Visual Neuroscience, 3:119-25, 1989).

 


 

© WIKTOR RZEZUCHOWSKChickens have four types of cone opsins (PNAS, 89:5932-36, 1992), and in some birds, the short-wavelength opsin is shifted to absorb in the ultraviolet. Bird cone cells also have an oil droplet that serves to filter or concentrate particular wavelengths of light.

 


 

© LEEKRIThe eye of the American chameleon (Anolis carolinensis) has no rods and uses multiple cone opsins to detect color. The peaks here show the maximum absorption of the photopigments reconstituted in vitro (Vision Research, 38:37-44, 1998).

 


 

© LOONGERIn its ocean habitat, the coelacanth (Latimeria chalumnae) receives only blue light. Correspondingly, its rod-enriched eyes absorb light in this range. The peak here represents the absorption maximum of the visual pigment in vitro (PNAS, 96:6279-84, 1999).

 


 

© LROCHKA_TLike many fish, goldfish can see in the ultraviolet, thanks to a shift in their short-wavelength opsin. Using their long-wavelength opsin (yellow peak), they can also see red, likely an adaptation to their shallow aquatic environment, in which red light is not filtered out (Genetics, 153:919-32, 1999).

 


 

DIDIER DESCIUENS/WIKIMEDIA COMMONSThe small white butterfly (Pieris rapae) expresses four types of opsins but has at least six types of photoreceptors (PLOS ONE, 5:e15015, 2010). Filters in the eye adjust the spectral sensitivity of the photoreceptor cells. In males, the violet receptor is modified into a second blue one (not shown).

 


 

© NANCY NEHRINGRepeated florets called ommatidia in the compound eye of the fruit fly (Drosophila melanogaster) are made of a central color-vision cell surrounded by six blue-light absorbing cells. Shown here are the absorption maximums for the opsins expressed in the central cell of the ommatidium (J Neurosci, 19:10716-26, 1999).

References

  1. M. Neitz et al., “Spectral tuning of pigments underlying red-green color vision,” Science, 252:971-74, 1991.
  2. J. Nathans, D.S. Hogness, “Isolation and nucleotide sequence of the gene encoding human rhodopsin,” PNAS, 81:4851-55, 1984.
  3. J. Nathans et al., “Molecular genetics of human color vision: The genes encoding blue, green, and red pigments,” Science, 232:193-202, 1986.
  4. G.H. Jacobs, J. Neitz, “Inheritance of color vision in a New World monkey (Saimiri sciureus),” PNAS, 84:2545-49, 1987.
  5. J. Nathans et al., “Molecular genetics of human blue cone monochromacy,” Science, 245:831-38, 1989.
  6. Y. Wang et al., “A locus control region adjacent to the human red and green visual pigment genes,” Neuron, 9:429-40, 1992.
  7. G.H. Jacobs et al., “Emergence of novel color vision in mice engineered to express a human cone photopigment,” Science, 315:1723-25, 2007.
  8. K. Mancuso et al., “Gene therapy for red-green colour blindness in adult primates,” Nature, 461:784-87, 2009.
  9. W. Makous, “Comment on ‘Emergence of novel color vision in mice engineered to express a human cone photopigment,’” Science, 318:196b, 2007.
  10. N.C. Benson et al., “Unsupervised learning of cone spectral classes from natural images,” PLOS Computational Biology, 10:e1003652, 2014.
  11. A.D. Melin et al., “Fig foraging by dichromatic and trichromatic Cebus capucinus in a tropical dry forest,” International Journal of Primatology, 30:753-75, 2009.
  12. A.D. Melin et al., “Food search through the eyes of a monkey: a functional substitution approach for assessing the ecology of primate color vision,” Vision Research, 86:87-96, 2013.

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Posts: 0

October 3, 2014

Loss of Olfactory Receptor Genes Coincides with the Acquisition of Full Trichromatic Vision in Primates That fact links RNA-directed nutrient-dependent DNA methylation and RNA-mediated events from ecological variation to amino acid substitutions and to gains and losses of protein function, which differentiate all cell types of all individuals of all species.

See for example: "...the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla." Dobzhansky (1973)

"RNA molecules function as the central conduit of information transfer in biology." That fact suggests theories about how color vision arose are based on assumptions linked to the invention of neo-Darwinism via the gene-centric approach of population geneticists who knew nothing about RNA-mediated events when they began to invent their theories.

It is surprising to see those theories integrated into this article as if they suddenly had any explanatory power given what is currently known about Alternative RNA Splicing in Evolution and about Nutrient-dependent/pheromone-controlled adaptive evolution: a model.

Until recently others have made claims like "...the evolution of trichromacy as well as huge increases in social complexity have minimised the role of pheromones in the lives of primates, leading to the total inactivation of the vomeronasal system in catarrhine primates while the brain increased in size and behaviour became emancipated from hormonal regulation." No experimental evidence of biologically-based cause and effect linked from biophysical constraints on amino acid substitutions and protein folding to cell type differentiation supports claims like that, either.

Re: "The results provided support for the idea that an ancient X-linked opsin gene underwent a single duplication event and that subsequent mutations in the copy shifted the absorbance spectrum of the photopigment.3"

It's not a good idea to suggest that the idea above has been supported by any experimental evidence that might otherwise link biologically-based cause and effect across species. First, sex differences in cell types must be explained. For example: "Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species..."

The bottom line appears to be that people willingly accept theories about how sex differences arose and about how color vision arose because they think the theories have been supported by experimental evidence, which links ecological variation to ecological adaptations via conserved molecular mechanisms in species from microbes to man. Until biologically-based evolutionary events are described, I hope that others will begin to examine details of RNA-mediated events that link cell type differentiation in all species from nutrient uptake to the pheromone-controlled physiology of reproduction and controlled biodiversity loosely associated  with color vision.

Close associations between frugivory in species that are blind as bats and cave fish link nutrient uptake in an atoms to ecosystems context that also links species-specific pheromones to control of cell type differentiation in the honeybee model organism and all other model organisms.

Primates should not be excluded from an atoms to ecosystems model of ecological variation linked to ecological adaptations via RNA-mediated events.

Avatar of: Centurion13

Centurion13

Posts: 1

October 3, 2014

How do they know it happened this way?  Seems like an awful LOT of 'fortuitous genetic events', if you ask me.  The problem is that evolution is assumed to be correct, and the tale spinning begins. 

But the truth, whatever it may be, can't rest on an endless string of assumptions.  Has anyone sat down and estimated the likelyhood of this sort of thing happening as the author would have us believe?  He wasn't there.  How could he possible know for sure?

I know some may say 'well, however unlikely, we have color vision, so it must have happened'.  But that's only if you start by assuming evolution by random chance is true.  What if it's not?  

That aside, the mechanics for this are brilliant.  The story told is very interesting, and that is even if I don't think it true (and I don't). 

Avatar of: Keith Loritz

Keith Loritz

Posts: 25

October 4, 2014

With all of the EMR data flying around now-a-days, prey, just like enemy combatants, would benefit by being able to SEE our various normally non-visible high-tech sprectral emissions unimpeded by vegetation. Perhaps deer, moose, elk will naturally evolve to see our cell and blue tooth emissions and leave the area. With no natural background emissions, this would yield excellent signal-to-noise detection rates. You want this ability to see cool colors. The military will want this/NEED THIS to have the advantage in a high tech fight. Expect a bunch of research money to come flooding your way when the higher ups in the military complex realize the potential benefits involved here: Soldiers that can see data transmissions without ANY added gear!

Avatar of:

Posts: 0

Replied to a comment from Centurion13 made on October 3, 2014

October 5, 2014

A universal trend of amino acid gain and loss in protein evolution

"We cannot conceive of a global external factor that could cause, during this time, parallel evolution of amino acid compositions of proteins in 15 diverse taxa that represent all three domains of life and span a wide range of lifestyles and environments. Thus, currently, the most plausible hypothesis is that we are observing a universal, intrinsic trend that emerged before the last universal common ancestor of all extant organisms."

Amino acid substitutions, which differentiate cell types in all cells of all individuals of all species, obviously preceded the structure and biological function of all proteins. Until someone describes an evolutonary event that links RNA-mediated (i.e., pre-mRNA and mRNA) changes in the structure and biological function of proteins, claims that there ever was a last universal common ancestor of all extant organisms sound suspiciously like pseudoscientific nonsense.

Avatar of: Kim Krieger

Kim Krieger

Posts: 2

October 7, 2014

This article is fascinating. Apparently tetrachromacy already appears in a few rare humans--sisters and mothers of colorblind men have four types of cones, three normal and one mutant. See this article, for example:

http://discovermagazine.com/2012/jul-aug/06-humans-with-super-human-vision

I'm sure that Neitz must be aware of such cases. These tetrachromats have enhanced red-green discrimination. But it sounds as if he's interested in expanded perception at the edges of existing sight. I'm curious what type of opsin he would use in his theoretical human experiment. Goldfish short-wave length opsin? Or that of chickens?

Avatar of: seescaper

seescaper

Posts: 1

October 12, 2014

We know that plasticity of the brain is greatest in childhood and decreases as one ages into adulthood. In terms of vision, the brain has filters that suppress information from a given eye in amblyopia. For instance, if the images coming from the two eyes are significantly different, such as in a large difference in refractive error, or if there is binocular diplopia secondary to strabismus, then the brain acts to suppress or partially suppress one of the images. If this continues into adulthood, the suppressed image cannot be undone, even if the causative condition is corrected. Another situation causing amblyopia is if one eye has a significant cataract. Lets say that such an eye can only resolve 20/80. Then, in adulthood, if this cataract is then treated, the eye will still never regain more than 20/80. But if treated as an infant, more normal vision might develop, as long as the eye received an implant or contact lens. So, for color vision, one might expect that an eye that was genetically modified to receive additional cones that would yield additional opportunities for the brain to create different color sensations, it might matter when in life this was done. If done in infancy, then the plasticity of the brain might be able to develop this ability. But, if an individual who never developed this ability in childhood was then endowed with new receptors, there might be an amblyopic effect to the new system. Even if it is there the brain might not be plastic enough to adapt. However, in an individual who had normal color vision throughout life but lost it secondarily to disease or injury, restoration of the original anatomy might be helpful in restoring the original color vision.

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