Antioxidants May Aid Cancer

Mice given a dietary supplement had faster-progressing melanoma, a study shows.

By | October 16, 2015

PUBLICDOMAINIMAGES, DEBORA CARTAGENA UCSDCPFor the second time this month, scientists have reported that antioxidant supplementation sped up cancer growth in mice with melanoma. In the latest study, published this week (October 14) in Nature, researchers fed mice a common dietary supplement and the animals ended up with more tumors and more widespread cancers.

“We discovered that metastasizing melanoma cells experience very high levels of oxidative stress, which leads to the death of most metastasizing cells,” Sean Morrison, director of the Children’s Medical Center Research Institute at University of Texas Southwestern Medical Center, said in a press release. “Administration of antioxidants to the mice allowed more of the metastasizing melanoma cells to survive, increasing metastatic disease burden.”

Morrison’s group gave mice N-acetylcysteine (NAC), an antioxidant used in some body-building supplements. In a study published last week (October 7) in Science Translational Medicine, Martin Bergo’s team at the University of Gothenburg in Sweden also gave mice with melanoma NAC and discovered twice as many lymph node metastases as mice on a normal diet.

“The challenges will be to understand how generally applicable are these observations to other tumor types and to translate these findings into clinically useful dietary guidelines,” Dimitrios Anastasiou, who studies cancer metabolism at the U.K.’s Francis Crick Institute and who was not involved in either study, told The Scientist earlier this month.

In 2014, Bergo’s group gave NAC to mice with lung cancer. Compared to control mice, the dosed mice developed larger tumors and they died sooner. The team showed that antioxidants reduced potentially damaging reactive oxygen species in tumor cells and reduced the activity of a tumor suppressor called p53.

“This is an extremely striking observation, but not surprising given the rather disappointing outcomes of patients at risk for developing lung cancer who had been treated with various antioxidants,” David Tuveson of Cold Spring Harbor Laboratory who was not involved in the work, told The Scientist at the time. “We should now consider whether people consuming high doses of antioxidants are ironically promoting cancers that they seek to prevent.”

Morrison told The Washington Post: “Personally, from the results we’ve seen, I would avoid supplementing my diet with large amounts of antioxidants if I had cancer.” He said cancer patients should continue eating antioxidants as part of a healthy diet. 

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Avatar of: DannyBoy

DannyBoy

Posts: 4

October 16, 2015

I wonder who's funding this research? The mice were genetically engineered to be prone to cancer so, anything you do to them creates devastating results. I read the original publication and the American Cancer Society and some smuck Dr. Allowing his name to be published for publicity and Ego, pushed this Bogus study because, NAC interferes with Chemotherapy! Anything that threatens the sales of Chemo, is labeled as Dangerous and is promoted as such. These Lies and BS will  soon be uncovered and brought to justice by the People who have been Lied to! Chemo causes Cancer and to utilize this to treat Cancer is INSANE! Mammograms also cause Breast Cancer! If there was a tiny tumor and you Smash it and Radiate it? DUH!  What's the typical outcome? Stupid Americans!

Avatar of: jhnycmltly

jhnycmltly

Posts: 2

December 16, 2016

Far cry from their 'antioxidants make expensive urine' speil .. eh.

So they are now saying antioxidants DO work but 'not in a good way' ..

Kind of strange though since the lastest in research of degenerative disease is that it is all caused by oxidative  stress .. and what is the treatment for oxidative stress .. ? .. antioxidants.

"Researchers uncover key mechanisms of cancer, aging and inflammation" 

"Oxidative stress—a condition where damaging molecules known as free radicals build up inside cell—accelerates telomere shortening. Free radicals can damage not only the DNA that make up telomeres, but also the DNA building blocks used to extend them" 

 

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