Opinion: Biodefense Innovation Needed

To protect against biological threats, federal agencies and other key stakeholders should commit to a strategic, unified approach.

By | October 28, 2015

WIKIMEDIA, NIAIDFrom the early days of space exploration, NASA assumed that astronauts could encounter extraterrestrial microorganisms during their missions. Would these organisms be entirely alien? Could they be detected? If they caused disease, could astronauts learn enough about them to determine treatments?

Over time, NASA innovations led to the development of detectors now used on the International Space Station (ISS) to locate and eradicate colonies of organisms before they interfere with astronaut health or ISS functioning (a remarkable lab-on-a-chip). Others approached the challenge from the perspective of life functions. For example, instead of trying to identify an entire organism, a detector could find evidence of biomarkers, metabolism, or even sound.

Exposure to novel microbes is not just an extraterrestrial concern. Pathogens seriously impact human health each day. Biodefense is the field of activity in which we work to predict, prevent, and respond to major infectious disease threats, whether they come from nature, terrorists, or lab accidents. Civilian and military planners determine which biological threats are most likely, and then develop the detectors and medical countermeasures needed to thwart them. Although their specific needs are different from NASA’s, their fundamental need to identify unknown organisms quickly is the same.

While the terrestrial approach may be logical for known threats, it requires currently unsustainable resources to address thousands of individual organisms known to cause morbidity and mortality. Organism-specific detection technology and laboratory protocols will prove insufficient to meet unsuspected or bioengineered threats. Threats from emerging diseases, genetic engineering, and antimicrobial resistance require a shift in thinking to address previously unseen organisms. What if today’s civilian and military agencies employed lateral thinking to develop capacities needed to rapidly identify immunogenic components of pathogens, deliver antigen payloads into platform technologies, and quickly manufacture medical countermeasures using flexible and adaptable technologies.

Much like the space program, success in this venture will require an enterprise: a sweeping set of individuals and institutions with wide-ranging capabilities, working together to achieve specific goals. But in biodefense, federal agencies and many companies often work alone. We need a comprehensive strategy combined with political and governmental know-how in the White House and in Congress to make the most of the funding to defend against intentionally introduced, accidentally released, and naturally occurring infectious diseases.

In 2014, we convened the bipartisan Blue Ribbon Study Panel on Biodefense—with Hudson Institute and the Inter-University Center for Terrorism Studies at the Potomac Institute for Policy Studies as institutional sponsors—to examine the state of our preparedness and develop responses to shortcomings. In our report “A National Blueprint for Biodefense: Leadership and Major Reform Needed to Optimize Efforts,” released today (October 28), we make it clear that it is time to centralize leadership and take a different approach to biodefense—one in which the entire biodefense enterprise is understood and driven by a central leader, its elements interconnected, and which values innovation, not as an end, but as a means. We elaborate on four areas in which either technological innovation or innovation in our governance of biodefense problems can lead to substantially beneficial developments: prioritizing innovation over incrementalism in medical countermeasure development; developing a modern biodetection and biosurveillance system capable of rapid identification; overhauling the Select Agent Program to meet new accountability needs in the 21st century; and building a global public health response apparatus predicated on public-private partnerships.

Astronomer Neil deGrasse Tyson has spoken of the virtues of “an innovation culture,” a culture that does not silo efforts by putting money toward solving singular problems in the short-term, but whose innovative investments transcend a single election cycle and provide broad benefit. This is precisely what a strategic, unified-budget approach to biodefense can accomplish. Innovation is not an office buried somewhere in the federal government—it is a state of mind, a cultural value proposition from which we can better defend against the threats of today and tomorrow.

Joe Lieberman and Tom Ridge cochair the Blue Ribbon Study Panel on Biodefense. Lieberman (D-CT) served 24 years in the United States Senate, where he spent six years as Chairman of the Senate Committee on Homeland Security and Governmental Affairs. He was the Democratic Party’s Vice Presidential nominee in 2000. Ridge (R-PA) was the nation’s first Secretary of Homeland Security. He also served as the 43rd Governor of Pennsylvania and six terms in the United States House of Representatives.

The Blue Ribbon Study Panel on Biodefense received institutional sponsorship from Hudson Institute and the Inter-University Center for Terrorism Studies. Senator Lieberman and Governor Ridge are joined by panelists Donna Shalala, former United States Secretary of Health and Human Services; former Senator Tom Daschle (D-SD); former Representative Jim Greenwood (R-PA); and the Honorable Ken Wainstein, former Homeland Security Advisor and Assistant Attorney General for National Security.

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Popular Now

  1. Unstructured Proteins Help Tardigrades Survive Desiccation
  2. What Budget Cuts Might Mean for US Science
    News Analysis What Budget Cuts Might Mean for US Science

    A look at the historical effects of downsized research funding suggests that the Trump administration’s proposed budget could hit early-career scientists the hardest.  

  3. Inflammation Drives Gut Bacteria Evolution
  4. Women Lose Vision After Stem Cell Treatment
Business Birmingham