Antibiotic Resistance Reaches Brazil

Scientists detect a colistin-resistance gene in a clinical sample.

By | August 8, 2016

FLICKR, VEEDUNNFor the first time in Brazil, a person has tested positive for carrying bacteria with the antibiotic-resistance gene mcr-1, which blocks the drug colistin. As researchers reported today (August 8) in Antimicrobial Agents and Chemotherapy, the bacterial plasmid resembled antibiotic-resistant strains present on other continents.

The gene had already cropped up in livestock in Brazil—in addition to animals, food, or humans in China, Asia, Africa, Europe, North America, and Argentina. In this latest case, a 60-year-old diabetic patient with a foot ulcer tested positive for E. coli bearing mrc-1. He had gone through multiple rounds of various antibiotics, and ended up having his foot amputated, the researchers noted in their paper.

The E. coli plasmid, called lncX4, which the researchers recovered from the patient was 99.9 percent similar in sequence to a Klebsiella pneumonia plasmid taken from a person in China and to an E. coli plasmid collected from a pig slurry in Estonia.

“What is surprising is the fact that the IncX4 plasmids bearing mcr-1 obtained from different bacterial species, belonging to different [sequence types], isolated in different clinical contexts and found in different continents are highly similar in the plasmid backbone sequences,” the authors wrote. “This strongly suggests that self-transmissible IncX4-type plasmids may represent promiscuous plasmids contributing to the intercontinental spread of the mcr-1 gene.”

Add a Comment

Avatar of: You



Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Popular Now

  1. Running on Empty
    Features Running on Empty

    Regularly taking breaks from eating—for hours or days—can trigger changes both expected, such as in metabolic dynamics and inflammation, and surprising, as in immune system function and cancer progression.

  2. Gut Feeling
    Daily News Gut Feeling

    Sensory cells of the mouse intestine let the brain know if certain compounds are present by speaking directly to gut neurons via serotonin.

  3. Government Nixes Teaching Evolution in Turkish Schools
  4. Athletes’ Microbiomes Differ from Nonathletes