Bioengineered ‘Pancreas’ Effective in First Patient

The diabetic volunteer continued to produce insulin one year after she received a transplant of abdominal islet cells.

By | May 12, 2017

Fluorescent islets transplanted in the abdomen, red indicating insulin and blue indicating cells’ nuclei

DIABETES RESEARCH INSTITUTE/UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE

 Type I diabetes had rendered a 43-year-old woman dependent on insulin, until doctors restored her body’s ability to produce the hormone with engineered islet cells transplanted into her abdomen, according to a New England Journal of Medicine report published today (May 11). The patient remained insulin-independent one year after her transplant, and as reported by a news release, is part of a continuous clinical trial testing the efficacy of this treatment for diabetes.

In type I diabetes, the body’s immune system attacks insulin-producing pancreatic beta cells—a subtype of islet cells. To restore insulin production and simultaneously curtail an immune response, researchers blended a donor’s islet cells with the patients’ plasma and, together with added enzymes that enable blood clotting, made a “gel-like material that [stuck] to the omentum” within her abdomen, according to the news release.

“The objective of testing this novel tissue-engineered platform is to initially determine that insulin-producing cells can function in this new site, and subsequently introduce additional technologies towards our ultimate goal to replace the pancreatic endocrine function lost in type 1 diabetes without the need for anti-rejection drugs,” Camillo Ricordi, a coauthor, physician, and professor at the University of Miami Miller School of Medicine, said in the news release.

In the study, the patient demonstrated increased glucose and decreased insulin beginning at six months post-transplant, but her bloodwork indicated that she had not yet returned to a diabetic condition.

“We’re exploring a way to optimize islet cell therapy to a larger population. This study gives us hope for a different transplant approach,” David Baidal, the lead author and a professor at the University of Miami Diabetes Research Institute, told reporters. 

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Comments

Avatar of: Paul Stein

Paul Stein

Posts: 220

May 12, 2017

Remarkable results.  Also remarkable is that it took this long to get these results.  Islet transplantation has been discussed for decades now.  What took so long?  What is the magic sauce here that had never been thought of before?

Avatar of: sierrabreanne

sierrabreanne

Posts: 1

May 19, 2017

they use aborted fetus' that planned parenthood and other abortion clinics SELL them. just thought everyone might want to know.

Popular Now

  1. A Coral to Outlast Climate Change
  2. Antarctica Is Turning Green
  3. First In Vivo Human Genome Editing to Be Tested in New Clinical Trial
  4. How to Tell a Person’s “Brain Age”
AAAS