Image of the Day: Smell You Later

Adult olfactory stem cells can be used to grow a smattering of cells important for smell, including scent-sniffing neurons and structurally supportive sustentacular cells. 

By | May 15, 2017

Neurons (green) grown from a single adult olfactory stem cell in a rat's olfactory tissue, sustentacular cells shown in magenta

RUSSELL FLETCHER & JOHN NGAI, UC BERKELEY

           (See R.B. Fletcher et al., “Deconstructing olfactory stem cell trajectories at single-cell resolution,” Cell Stem Cell, doi:10.1016/j.stem.2017.04.003, 2017.) 

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Avatar of: James V. Kohl

James V. Kohl

Posts: 453

May 15, 2017

Deconstructing Olfactory Stem Cell Trajectories at Single-Cell Resolution

"...provides a model for deconstructing similar hierarchies in other stem cell niches."

See also: Nutrient-dependent/pheromone-controlled adaptive evolution: a model

THIS MODEL DETAILS HOW CHEMICAL ECOLOGY DRIVES ADAPTIVE EVOLUTION VIA: (1) ecological niche construction, (2) social niche construction, (3) neurogenic niche construction, and (4) socio-cognitive niche construction. This model exemplifies the epigenetic effects of olfactory/pheromonal conditioning, which alters genetically predisposed, nutrient-dependent, hormone-driven mammalian behavior and choices for pheromones that control reproduction via their effects on luteinizing hormone (LH) and systems biology.

My model compliments the representations of biophysically constrained niche construction in Feedback loops link odor and pheromone signaling with reproduction

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The virus-driven degradation of messenger RNA has since been linked from mutations to all pathology via a game that presents facts about cell biology to anyone age 10 or older.

Cytosis: A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

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