Spheroid Cell Culture: New Dimensions in 3D Assays from thescientistllc on Vimeo.
High attrition in clinical trials and the need to replace animal models in a variety of applications has driven researchers to develop in vitro assays with greater physiological relevance. The last decade has seen a large variety of models developed to mimic cells organized into tissues and even organs. These have collectively been termed 3-D cell culture models. 3-D methods are deemed superior to growing cells in a monolayer due to increased extracellular matrix (ECM) formation, cell-to-cell and cell-to-matrix interactions, all important for differentiation, proliferation and cellular functions in vivo. Currently, the most popular method of 3-D cell culture is aggregating cells into spheroids. The Scientist is bringing together a panel of experts to discuss the value of spheroid culture systems, and to explore the technical benefits and challenges of making the switch from 2-D to 3-D...
Topics to be covered:
- Using 3-D culture to turn individual cells into organoids and organs
- Novel options for 3-D culture scaffolding
Meet the Speakers:
Esmaiel Jabbari, PhD
Professor, Chemical Engineering, Biomedical Engineering
College of Engineering and Computing, University of South Carolina
Margaret Magdesian, PhD
Founder and CEO
Ananda Devices
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