Driving Out Disease

Volume 31 Issue 1 | January 2017

Cover Story

Using Gene Drives to Limit the Spread of Malaria

By | January 1, 2017

Introducing genetic changes into mosquito populations could be key to effective malaria control.

Featured Articles

image: Forensics 2.0

Forensics 2.0

By | January 1, 2017

Meet the researchers working to untangle the mystery of a Missouri home filled with bones by bringing cutting-edge technologies into the crime lab.

image: Repurposing Existing Drugs for New Indications

Repurposing Existing Drugs for New Indications

By | January 1, 2017

An entire industry has sprung up around resurrecting failed drugs and recycling existing compounds for novel indications.

Departments

Contributors

Contributors

Meet some of the people featured in the January 2017 issue of The Scientist.

Editorial

Gene Drives and Other Controversies

Aedes and Anopheles control; three-parent babies; the PhD glut

Speaking of Science

Notable Science Quotes

Science under Trump, gene drive, medical marijuana, and more

Notebook

Reconstructing the Effects of the Fur Trade in the Brazilian Amazon

Researchers use a century of trade records to uncover differences in the resilience of terrestrial and aquatic species.

How an Invasive Bee Managed to Thrive in Australia

The Asian honeybee should have been crippled by low genetic diversity, but thanks to natural selection it thrived.

Caribbean Anoles Function as Model Organisms for Evolutionary Dynamics

The small lizards adapted to unique niches among dozens of isles.

Notebook

Researchers Track Eels on Their Cross-Atlantic Migration

A mysterious migration is coming to light after more than a century of study.

Critic at Large

Opinion: Ethical Considerations of “Three-Parent” Babies

Mitochondrial replacement therapy raises important societal and ethical concerns, but should be embraced for its utility in preventing disease.

Modus Operandi

New Technique Enables Observation of Accessible Chromatin

A test tube-based genome-labeling technique has been brought under the microscope.

The Literature

RNA Sequences Don’t Predict In Vivo Transcript Structure

Eukaryotes prevent secondary RNA structures called G-quadruplexes, commonly observed in vitro, from forming in the cell. 

Newly Found White Blood Cell Withstands Chemotherapy

Vaccine-induced macrophages open a new realm of study into remodeling the immune system to reduce the risk of infections during cancer treatment.

Transgenerational Epigenetics Prepares Plants for Drought

Plants grown in dry soil produce offspring that are hardier in drought conditions, and DNA methylation appears responsible. 

Profile

Methylation Maestro

After initially discovering that DNA methylation represses transcription, Howard Cedar continues to explore how the epigenetic mark regulates gene expression.

Scientist to Watch

Jeremy Day Probes Reward Signaling in the Brain

The University of Alabama, Birmingham, researcher seeks the neural roots of animal behavior

Lab Tools

Characterizing the Imprintome

Three techniques for identifying the collection of maternal and paternal genes silenced in offspring

Careers

Addressing Biomedical Science’s PhD Problem

Researchers and institutions seek to bridge the gap between emerging life science professionals and available positions.

Reading Frames

Moving Past the Myth of a Simple Biological Difference Between the Sexes

The public may still believe that male-specific traits, such as high testosterone levels, lead to many of the gender inequalities that exist in society, but science tells a different story.

Foundations

The Sled Dogs that Stopped an Outbreak

Balto, Togo, and other huskies famously delivered life-saving serum to a remote Alaskan town in 1925—but newspapers didn’t tell the whole story. 

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