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Crystal Illumination
The Scientist 2004, 18(1):36
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While research in structural genomics is receiving a giant boost from the automated devices on the market, one sector is still stumping even the best crystallizers: membrane proteins. The vast majority of drugs target membrane proteins, such as receptors, making crystallization of membrane proteins a priority, says Martin Caffrey, a structural biologist at the University of Limerick, Ireland. Yet current crystallization methods don't work for membrane proteins that have hydrophobic membrane-embedded regions, which avoid the water that's central to the principles of vapor diffusion and microbatch.
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