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RNAi Inches Toward the Clinic
As genome-wide research efforts continue, drug developers eye possible therapeutic approaches
The Scientist 2004, 18(6):32
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When Andrew Fire of the Carnegie Institution in Washington, DC, set out to understand some confusing results obtained with antisense RNA in 1998,[1]
he could not have known he was firing the opening salvo in a biotech revolution. What he stumbled upon was a potent and simple way to knock down gene expression in eukaryotic cells called RNA interference, or RNAi.
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