The Scientist : A New Pathway for Inositol [10/5/2004]

The Scientist 2004, 18(9):14

10 May 2004

In the mid 1980s we discovered a phosphatidylinositol kinase that co-purified with several oncoproteins and that correlated with cell transformation. When my graduate student Malcolm Whitman presented his results at a lab meeting, I noticed that in this autorad, the phosphatidylinositol phosphate produced by the oncoprotein-associated PI kinase (Type I) migrated slightly more slowly in thin layer chromatography (TLC) than that produced by PI 4-kinase (Type II).

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