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Vaccine Trials Sobered by Breakthrough Mutation
Hopes persist despite HIV escapee
The Scientist 2004, 18(11):28
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Clinical research by nature begets clichés: ups and downs, one step forward, one step back. So it goes for a pair of back-to-back papers from 2002. This issue's first Hot Paper reports early success of an HIV-vaccine approach based on a cytotoxic T lymphocyte (CTL) response to viral gag protein.[1]
The second describes one of eight immunized monkeys that succumbed to AIDS-like illness after a breakthrough mutation enabled a challenge virus to evade protection from a similar vaccine.[2]
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