Eukaryotic gene regulation as a field has matured much during decades of study, but understanding it on a genome-wide basis has started in earnest only with the assembly of genomic data. Identifying genome-wide regulatory motifs is problematic due to their typically low consensus sequences; grasping which transcription factors bind to such motifs is even more difficult, as numerous factors can bind to any one motif. Nonetheless, with many diseases linked to malfunctions in transcription factors, and many cellular processes relying on multitiered transcriptional regulation, this information is invaluable.