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The DNA Jet Set
The Scientist 2004, 18(12):36
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Scientists have tried at least four methods for delivering nucleic acids to mammalian tissues for the purpose of inducing exogenous gene expression: scarifying the epithelium with a razor blade, then smearing the skin with DNA; scratching the skin with the back of an 18-gauge needle followed by smearing on of DNA; intradermal inoculation and puncture 200 times with a 27-gauge needle; and interdermal inoculation using a jet injector. The first two techniques didn't work very well, but according to Priscilla Furth, of Georgetown University's Lombardi Cancer Center, the last method does.
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