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Driving Changes in Ligand Theory
Better understanding of receptor activation may alter drug design
The Scientist 2004, 18(15):32
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Pharmacologists traditionally divide ligands into agonists, which stimulate receptors, and antagonists, which bind to receptors and block endogenous mediators. According to the conventional view, the agonist fits into the receptor, like a key fits a car's ignition, switching on the internal machinery. Antagonists fit the ignition, but block endogenous transmitters.
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