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Stem Cell Sculpting
Study notes the power of shape on cell differentiation
The Scientist 2004, 18(16):22
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Researchers have tried for years to make stem cells differentiate into specific cell types. This work usually involves bathing the cells in molecular signals that affect their fate. Some are finding, though, that cellular shape may be at least as influential as signal molecules in the differentiation process. This adds to a growing literature suggesting that cellular spatial structure affects many activities, including proliferation, apoptosis, and tumorigenesis.
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