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Class (Switch) Wars
Debating AID's role in antibody diversification
The Scientist 2004, 18(18):28
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A battle of sorts has been brewing over the contribution to antibody diversity made by a B-cell specific protein called activation-induced cytidine deaminase (AID). This issue's Hot Papers present AID as a DNA mediator and dismantle predictions that AID works on RNA. By clearing some experimental inconsistencies, the new hypothesis has become popular, but not everyone agrees with the newfound DNA-editing role.
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