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Monitoring Neural Activity In Vivo
New fosGFP transgenic mice light up as they learn
The Scientist 2004, 18(18):42
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Scientists at Carnegie Mellon University in Pittsburgh have created a transgenic mouse that will allow researchers to visualize patterns of activity directly in individual neurons in vivo.[1]
To create the animals, Alison Barth and colleagues coupled the c-fos promoter, which is typically activated during neural activity, to a green fluorescent protein (GFP) marker. "By coupling c-fos activation to the expression of GFP, I could now see cells that were specifically implicated by particular stimuli, and specifically stimuli in vivo," Barth explains.
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