Communication between neurons – the stuff of our senses, emotions, and memories, as well as motor and visceral control – relies on chemical messengers. Packaged into tiny membrane-enclosed vesicles, neurotransmitters are delivered when a nerve impulse induces exocytosis. In addition to delivering the message to the receiving neuron, neuro-transmission results in changes to the sending neurons, which lose transmitter-loaded vesicles and grow larger as spent vesicles are incorporated into the plasma membrane. Synaptic vesicle recycling resolves both of these changes by pinching off new vesicles from the cell surface for reloading.