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Life Without Glutamate
A VGLUT1 knockout mouse elucidates glutamate neurotransmission
The Scientist 2004, 18(20):20
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A brain without glutamate, the major excitatory neurotransmitter in mammals, is quite literally unthinkable. Yet, knockout mice lacking the crucial vesicular glutamate transporter, VGLUT1, can live for up to a few months. This unexpected finding has enabled two research groups to investigate the function of VGLUT1.
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