Few voters in next week's US presidential election will embrace absolutely everything that either candidate stands for, or, for that matter, reject absolutely everything. Nevertheless, a change must be made, judged on a few key issues. The most pressing issues include the quagmire that is Iraq, national security, healthcare provision, and the economy. But science should not be too far behind, and anyone with the best interests of science at heart will have no hesitation in selecting John Kerry over George Bush.