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Turning the Tuberculosis Bacterium Lineage on its Head
Human scourge succumbs to sequence analysis
The Scientist 2004, 18(21):18
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Not long after the genome sequence of Mycobacterium tuberculosis was released in 1998,[1]
it began paying scientific dividends. This issue's Hot Papers offered insight into how Mycobacterium changed and evolved. One paper worked at the "micro" timescale, examining genomic differences among laboratory and clinical strains of M. tuberculosis. The other, looking on a "macro" timescale, reported a novel hypothesis for the evolutionary relationship of several Mycobacterium lineages.
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