Since its inception in 1997, the AMDeC Foundation, Inc. (AMDeC), a not-for-profit consortium of 35 of New York's preeminent medical schools, academic health centers, and major medical research institutions, has paved the way for its members to participate in large-scale collaborations. Such initiatives are now heralded as essential for translational and cross-institutional approaches to biomedical research. AMDeC actively works with its members to foster partnerships for basic-science and clinical research projects, to build genomics and other core facilities, and to expand New York's research infrastructure. Two of its flagship initiatives include the Integrated Genomics Program and the New York Cancer Project.