Sir2: Scrambling for Answers :The Scientist [6/12/2004]

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by Maria W Anderson

RESEARCH

Sir2: Scrambling for Answers

Researchers have yet to solidify links for the proposed longevity lynchpin

Email: Maria W Anderson - manderson@the-scientist.com
The Scientist 2004, 18(23):20

Published

6 December 2004

Low-calorie diets extend lifespan in almost every model tested, but scientists can't yet agree on what controls this phenomenon. The histone deacetylase Sir2 provides a seductive link between gene silencing and calorie restriction (CR),[1] but many debate the mechanism. Now researchers are turning to a new question: Does Sir2 have a role in CR-mediated longevity at all? While some still believe that Sir2 is the lynchpin of the CR-longevity pathway, others are more skeptical and propose alternative mechanisms. Recent findings haven't clarified the issue.


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