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Gene Association Studies Typically Wrong
Reproducible gene-disease associations are few and far between
Email: Jack Lucentini - jlucentini@the-scientist.com The Scientist 2004, 18(24):20
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The first published study linking gene to disease is often far from the last word on the subject. Marc-Antoine Crocq, a psychiatrist with the Centre Hospitalier de Rouffach in France, learned this firsthand after leading a 1992 study on a mutation in the dopamine D3 receptor in the brain.[1]
The study found that people with two copies of the mutation have a schizophrenia risk roughly two to four times higher than others. Partly because these ratios were so high, and because the finding came from two independent teams, it looked strong. It was also, as it turns out, quite likely wrong.
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