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Mice tolerate siRNAs
The Scientist 2004, 18(24):24
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Small interfering RNAs (siRNAs) appear to silence genes in mice without triggering an immune response, according to researchers at the California Institute of Technology in Pasadena. Mark Davis and colleagues gave mice naked synthetic siRNAs against fatty acid synthase (FAS), c-MYC, or luciferase, through intraperitoneal injections or via the tail vein using either low-pressure (1% volume/weight) or high-pressure (10% volume/weight) methods.
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