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Engineering attenuation
The Scientist 2004, 18(24):24
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By exploiting a malaria parasite's "Achilles heel," researchers in Germany say a transgenic whole-organism vaccine for humans may be possible. A group headed by Stefan H.I. Kappe at Heidelberg University School of Medicine induced complete protection against malaria in mice by infecting them with living Plasmodium berghei lacking a single gene, known as UIS3 (for upregulated in infectious sporozoites gene 3).[1]
But safety and production issues could prevent the development of the vaccine for humans, say others.
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