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HIV/Host Interaction Elucidated
Research uncovers a deaminating defense mechanism that HIV bypasses
Email: Nicole Johnston - njohnston@the-scientist.com The Scientist 2005, 19(1):19
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Viruses are masters of disguise when it comes to slipping past host-mediated defenses. But one disguise in particular, which HIV uses, appears a particularly vulnerable target that renders the virus harmless in some cells. Virion infectivity protein (Vif), found in primate and human immunodeficiency viruses such as HIV-1, is required during the late stages of virus production for replication and establishing infection in vivo. It promotes infection by suppressing an innate cellular defense mechanism in human T lymphocytes.
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