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The Immune System as a Tool for Directed Evolution
New method takes advantage of iterative somatic hypermutation to generate novel fluorescent proteins
The Scientist 2005, 19(2):33
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A team of researchers at the University of California, San Diego, has harnessed the body's ability to tweak antibody genes to drive protein evolution in the lab. The group, led by Howard Hughes Medical Institute Investigator Roger Tsien, used the technique to induce the development of novel fluorescent properties in a red-fluorescent protein.[1]
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