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Challenging Dose-Response Dogma
Hormesis presents a good model for toxicological risk assessment – and it's not homeopathy
Email: Edward J. Calabrese - edwardc@schoolph.umass.edu The Scientist 2005, 19(3):22
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The central pillar upon which toxicological assessments are built is the dose-response relationship. But reliance on theoretical prediction models for dose response creates a wolf-crying atmosphere that generates fear and superfluous costs to the public. A better alternative exists, however. A rich vein of data supports hormetic dose-response modeling, which allows for the observation that some toxins, in small amounts, confer benefits rather than harm.
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