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Antibody Microarrays Highlight Enzyme Activity
New platform enables examination of complex proteomes
The Scientist 2005, 19(3):32
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When it comes to enzymes, protein abundance does not necessarily translate into protein activity: Post-translational modifications such as phosphorylation can dramatically alter enzyme function. Researchers traditionally have overcome this discrepancy with activity-based protein profiling (ABPP), which screens enzyme activity using probes that bind covalently to active sites.
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