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A Matter of Life and Cell Death
Solidifying PARP's role in DNA repair and apoptosis
Email: Stuart Blackman - sblackman@the-scientist.com The Scientist 2005, 19(4):22
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A cell has more than one option when it comes to protecting itself and surrounding tissues against the repercussions of DNA damage. One approach is repair; another is to cut losses and sacrifice itself. Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that appears to play a hand in both DNA repair and cell death.
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