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Cryo-Neutron Protein Crystallography Produces Sharper Structures
Crystallography at 15K pinpoints protein and solvent hydrogen positions
The Scientist 2005, 19(4):34
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X-ray crystallography has long been the method of choice for obtaining atomic-resolution protein structures, but it doesn't provide the whole picture. Hydrogen atoms, particularly labile hydrogens that interact with solvent, are often lost in the noise. "It is exceedingly difficult – usually impossible – to see a single hydrogen atom with X-rays," says Dean Myles, a crystallographer at the Oak Ridge National Laboratory (ORNL) in Tennessee and director of the facility's center for structural molecular biology.
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