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Making sense of antisense
The Hebrew University Jerusalem, IsraelEmail: Jack Cohen - jcohen@md.huji.ac.il The Scientist 2005, 19(5):8
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Thank you for your article on antisense[1]
and for letting us know that the subject is very much alive. Although antisense is an "RNA therapeutic" in that the target is mRNA, actually in almost all cases the oligomer used is a synthetic DNA analog, so to describe it as "antisense RNA" is incorrect.[2]
There is antisense RNA, but it is generally generated by a gene therapy type approach, while almost all the synthetic drug analogs are DNA.
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