More to Ab specificity than variable region :The Scientist [28/3/2005]

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by Janardan P Pandey

LETTERS

More to Ab specificity than variable region

Medical University of South Carolina, Charleston

Email: Janardan P Pandey - pandeyj@musc.edu
The Scientist 2005, 19(6):10

Published

28 March 2005

Although your article on therapeutic monoclonal antibodies was informative,[1] I would like to comment on a widespread misunderstanding of immunology by those engaged in engineering mouse-human chimeric antibodies. They mistakenly assume that the variable region of the antibody molecule is the sole determinant of antibody specificity. Miller et al. demonstrated more than two decades ago that the constant region influences the expression of variable-region determinants.[2] Several reports since have established the validity of this observation, the most recent in the current issue of Journal of Immunology.[3]


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