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A Picture of NF-κB Signaling
Approaching from different directions, researchers explore actions of the feted transcription factor
Email: Aileen Constans - aconstans@the-scientist.com The Scientist 2005, 19(6):22
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The transcription factor NF-κB exists in unstimulated cells as a cytoplasmic homo- or heterodimer bound to inhibitory IκB protein. NF-κB has received a great deal of attention since its discovery more than two decades ago, and for good reason. It regulates genes implicated in innate immunity, inflammation, cancer, and apoptosis. And the molecules associated with the NF-κB signaling pathway are prime drug targets.
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