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Human Epigenome Project Maps MHC Locus
Researchers to map methylation genome-wide
The Scientist 2005, 19(6):34
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Methylation at regulatory regions, especially promoters, correlates with transcriptional activity: Sequences near silent genes generally are methylated, whereas those near active regions are not. Scientists traditionally have measured these modifications on a gene-by-gene basis, but a team at the Wellcome Trust Sanger Center in Cambridge, UK, has been attacking the question on a genomic scale. This project, dubbed the Human Epigenome Project, released its first results in December 2004.[1]
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