Pain research has been enriched by remarkable discoveries during the past three decades leading to an unprecedented understanding of underlying mechanisms. But in spite of these discoveries, little has been translated into effective pain therapy. Pain research should take a page from cancer research. Instead of searching for a single drug panacea, we should dwell on the differences in pain conditions and pursue multiple treatment approaches. There will not be one magic bullet for all pains. Rather, to effectively characterize and treat the broad spectrum of pain experiences, we will need to take advantage of the latest technical approaches in genomics and proteomics.