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Gateways to Pathological Pain
Signal transduction and the immune system
Email: Jill U Adams - juadams@the-scientist.com The Scientist 2005, 19(Supplement 1):s24
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Peripheral nerves serve as pain's first messengers, firing action potentials as far as three feet to the spinal cord, where they alert the next nerve en route to the brain. Tissue damage and inflammation can lower nociceptor thresholds and increase neuronal excitability. The result is heightened pain sensitivity, a protective device, which resolves when the tissue heals.
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