The Scientist : Pain Hypersensitivity and Morphine Tolerance: Shared Mechanisms? [28/3/2005]

Pain Hypersensitivity and Morphine Tolerance: Shared Mechanisms?

The Scientist 2005, 19(Supplement 1):s26

28 March 2005

Repeated administration of morphine renders animals tolerant to the drug and hypersensitive to pain. These two effects are strikingly similar to those induced by nerve injury. Researchers have hypothesized about a shared mechanism and have investigated neurotransmitters and signal-transduction pathways in neurons. Joyce DeLeo of Dartmouth Medical School wondered about immune cell involvement.

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