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TCAS: The Complex Analgesics
The Scientist 2005, 19(Supplement 1):s36
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In the 1960s, researchers found that tricyclic antidepressants (TCAs) alleviated neuropathic pain, such as postherpetic neuralgia. For 40 years, however, TCAs' mode of action remained mysterious. Now some hints as to a possible mechanism, which encompasses actions at Na+ channels and neuronal plasticity, are beginning to emerge.
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